Cardiology and Cardiothoracic-Vascular Surgery

Research & Education > TriHealth Hatton Research Institute

In the early 1970s, Good Samaritan Hospital began to participate in prominent cardiac research efforts, thus establishing a reputation for leadership in cardiology. The TriHealth Hatton Research Institute now builds upon that reputation by helping to expand the robust group of cardiac and cardiothoracic/vascular clinical trials at Good Samaritan and Bethesda North hospitals. Specifically, the TriHealth Hatton Research Institute assists researchers in identifying and conducting research studies, as well as maintaining the proper compliance measures.

Both Bethesda North Hospital and Good Samaritan Hospital are composed of a research supervisor, a research / regulatory assistant, and research nurses who serve as study coordinators. The TriHealth Hatton Research Institute's cardiac and cardiothoracic/vascular research team has an average of 20 years of experience in critical care nursing.

The cardiac and cardiothoracic/vascular clinical trials listed below are currently being conducted to target the prevention or treatment of specific diseases and promote heart and vascular health. For more information, please call the appropriate contact person.

Currently Enrolling Clinical Trials

Cardiology Research

The AMPLATZER™ Post-infarct Muscular VSD Occluder Humanitarian Device Exemption (H070005) Post Approval Study. Learn More.

Principal Investigator and Contact Information:
Puvi Seshiah, MD
513 246 2000

Study Coordinator and Contact Information:
Anne Voorhorst, RN
513 865 1148
anne_voorhorst@trihealth.com

Apixaban for the Reduction of Thrombo-Embolism in patients with Device-Detected Sub-Clinical Atrial fibrillation (ARTESiA). Learn More.

Principal Investigator and Contact Information:
Marshall Winner, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

Pivotal Study Of A Dual Epicardial & Endocardial Procedure (DEEP) Approach for Treatment of Subjects with Persistent or Long Standing Persistent Atrial Fibrillation with Radiofrequency Ablation. Learn More.

Principal Investigator and Contact Information:
Gaurang Gandhi, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

A Multicenter, Prospective, Parallel-Group, Double-Blind, Randomized, Placebo-Controlled, Phase 2 Study of ANG-3777 (formerly BB3) to Assess the Safety and Efficacy of ANG-3777 in Patients Developing Acute Kidney Injury After Cardiac Surgery - The GUARD Study (Guard Against Renal Damage). Learn More.

Principal Investigator and Contact Information:
Louis Brunsting III, MD
513 865 5120

Study Coordinator and Contact Information:
Anne Voorhorst, RN
513 865 1148
anne_voorhorst@trihealth.com

Prospective Evaluation of Open Irrigated Ablation Catheters with High Resolution Mapping to treat Paroxysmal Atrial Fibrillation (INTERRUPT AF). Learn More.

Principal Investigator and Contact Information:
Marshall Winner, MD
513 246 2000

Study Coordinator and Contact Information:
Anne Voorhorst, RN
513 865 1148
anne_voorhorst@trihealth.com

Multi-Centre, Randomized, Double-Blind, Placebo-Controlled, Efficacy, and Safety Study of Etripamil Nasal Spray for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia – The RAPID Study (NODE-301 Part 2). Learn More.

Principal Investigator and Contact Information:
Gaurang Gandhi, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

Multi-Centre, Multi-National, Open Label, Safety Study of Etripamil Nasal Spray for Patients with Paroxysmal Supraventricular Tachycardia (Milestone 303). Learn More.

Principal Investigator and Contact Information:
Gaurang Gandhi, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

A multicenter, randomized, double-blind, double-dummy, parallel group, active controlled study to evaluate the effect of sacubitril/valsartan (LCZ696) versus valsartan on changes in NT-proBNP and outcomes, safety, and tolerability in HFpEF patients with acute decompensated heart failure (ADHF) who have been stabilized during hospitalization and initiated in-hospital or within 30 days post-discharge (PARAGLIDE-HF). Learn More.

Principal Investigator and Contact Information:
Freidoon Ghazi, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

Women’s Ischemia Trial to Reduce Events in Non-Obstructive CAD (WARRIOR). Learn More.

Principal Investigator and Contact Information:
Kamal Shemisa, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

Vascular Research

CAROTID REVASCULARIZATION AND MEDICAL MANAGEMENT FOR ASYMPTOMATIC CAROTID STENOSIS TRIAL (CREST-2) PROTOCOL. Learn More.

Principal Investigator and Contact Information:
Patrick Muck, MD
513 246 2000

Study Coordinator and Contact Information:
Anne Voorhorst, RN
513 865 1148
anne_voorhorst@trihealth.com

Assessment of the Gore Excluder Conformable AAA Endoprosthesis in the Treatment of Abdominal Aortic Aneurysms. Learn More.

Principal Investigator and Contact Information:
Patrick Muck, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

Evaluation of the Pantheris OCT-Imaging Atherectomy System For Treatment of In-Stent Restenosis (ISR) Lesions in Lower Extremity Arteries (INSIGHT IDE). Learn More.

Principal Investigator and Contact Information:
Patrick Muck, MD
513 246 2000

Study Coordinator and Contact Information:
Anne Voorhorst, RN
513 865 1148
anne_voorhorst@trihealth.com

STRIDE: A Study of Patients with Lower Extremity Acute Limb Ischemia to Remove Thrombus with the Indigo® Aspiration System. Learn More.

Principal Investigator and Contact Information:
Patrick Muck, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

Upcoming Clinical Trials

Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP II TR): A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCAL Transcatheter Valve Repair System and optimal medical therapy (OMT) compared to OMT alone in patients with tricuspid regurgitation. Learn More.

Principal Investigator and Contact Information:
Puvi Seshiah, MD
513 246 2000

Study Coordinator and Contact Information:
Lavonda Kirkland, RN
513 862 2877
lavonda_kirkland@trihealth.com

Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip in patients with mitral regurgitation. Learn More.

Principal Investigator and Contact Information:
Puvi Seshiah, MD
513 246 2000

Study Coordinator and Contact Information:
Anne Voorhorst, RN
513 865 1148
anne_voorhorst@trihealth.com

Left Atrial Posterior Wall and PV Isolation Using Cryoballoon for Treatment of Persistent AF (PIVoTAL-IDE). Learn More.

Principal Investigator and Contact Information:
Dilesh Patel, MD
513 246 2000

Study Coordinator and Contact Information:
Anne Voorhorst, RN
513 865 1148
anne_voorhorst@trihealth.com

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